Dental Restorations Effect on Oxidative Status of the Gingival Crevicular Fluid

Ervin Taso88 enrolled

Overview

The goal of the study was to ascertain the influence of dental caries and teeth position as well as the type and amount of the applied dental materials (DMs) on the oxidative stress (OS) status in gingival crevicular fluid (GCF).

Six DMs were tested by investigators, each sealed in one session: amalgam (Amg), zinc phosphate cement (ZnPhC), zinc polycarboxylate cement (ZnPoC), glass ionomer cement (GIC) and composites, Tetric EvoCeram (TEC) and Beautifil (BF). The study included 88 dental outpatients. Oxidative stress parameters, including malondialdehyde (MDA), glutathione (GSH) and total superoxide dismutase (tSOD) activity were measured in GCF, before (day 0) and after treatment (7th and 30th day). Antagonistically positioned healthy teeth were used as a control.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

HEALTH_SERVICES_RESEARCH

Masking

NONE

Enrollment

Conditions

Pharmacological Action

Interventions

Amalgam placementPROCEDURE

Before the Amg was sealed GCF was taken, and then taken again on the 7th and 30th days after the applied treatment.

Tetric EvoCeram placementPROCEDURE

Before the TEC was sealed GCF was taken, and then taken again on the 7th and 30th days after the applied treatment.

Beautifil placementPROCEDURE

Before the BF was sealed GCF was taken, and then taken again on the 7th and 30th days after the applied treatment.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: Criteria related to the condition of teeth: * Presence of proximal caries on anterior and posterior teeth * Existence of the antagonistic tooth ("mirror"-positioned healthy tooth) to be used as control * An absence of fresh post-extraction or traumatic wounds in the restoration area or in the area of restored surfaces * An absence of infection in the area of restored surfaces Other influencing criteria: * Absence of bone-associated diseases or treatments * Satisfactory oral hygiene * Patients exhibiting good compliance Exclusion Criteria: Criteria related to the condition of teeth: * Endodontic and/or periodontal infections in the area of the cervical filling * Presence of periodontopathy * Prominent periodontal pockets * Subgingival carries * Prominent fillings outside the cavity Other influencing criteria: * Patients on radiation or immunosuppressive therapy * Presence of bone-associated diseases and malignant diseases * Patients using drugs/alcohol/cigarettes (\> 20 cigarettes per day) * Bad oral hygiene * Patients exhibiting poor compliance

Locations (1)

Military Medical Academy

Belgrade, Serbia

Outcomes

Primary Outcomes

Changes in the levels of MDA in dental patients GCF after the applied treatments

The concentration of MDA in GCF was measured before (0 day) and twice after the applied treatments (7th and 30th days). GCF was taken via the intracervical absorption technique. Control GCF (from mirror-positioned health teeth) was taken once before the treatment.

Time frame: 0th, 7th and 30th days.

Secondary Outcomes

Changes in the levels of GSH in dental patients GCF after the applied treatments

Concentration of GSH in GCF was measured before (0 day) and twice after the applied treatments (7th and 30th days). GCF was taken via the intracervical absorption technique. Control GCF (from mirror-positioned health teeth) was taken once before the treatment.

Time frame: 0th, 7th and 30th days.

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.