A Study of the Use of Hepatitis C Positive Donors for Hepatitis C Negative Lung Transplant Recipients With Post-transplant Treatment With Mavyret

Inclusion Criteria: Recipient criteria: * Listed for an isolated lung transplant at NYU Langone Health * Between 18-70 years of age * Able to travel to the NYU Langone Health for routine post-transplant visits and study visits for a minimum of 6 months after transplantation * No active illicit substance abuse * Weight at least 40kg * Women of childbearing potential must agree to use birth control in accordance with Mycophenolate Risk Evaluation and Mitigation Strategy (REMS) after transplant due to the increased risk of birth defects and/or miscarriage * Both men and women must agree to use at least one barrier method after transplant to prevent any secretion exchange * Able and willing to provide informed consent Donor criteria: * Detectable HCV RNA by nucleic acid test (NAT) or positive anti-HCV antibody * Donor lung meets standard NYU Langone Health clinical criteria for procurement Exclusion Criteria: Recipient criteria: * HIV positive * HCV RNA positive or history of previously treated HCV * Evidence of active hepatitis B infection or on active antiviral treatment for HBV * Pregnant or nursing (lactating) women * Use of strong CYP3A inducers * Requires multi-organ transplant Donor criteria: * Confirmed HIV positive * Confirmed HBV positive (positive hepatitis B surface antigen, and/or detectable Hepatitis B virus DNA) * Known previously failed treatment for HCV * Donor age \>60 years