Hepatitis E Infection : Emergence Mechanisms in North-Eastern France of Polymorphic Clinical Forms.

Central Hospital, Nancy, France40 enrolled

Overview

The present research aims to collect virological and clinical data on hepatitis E virus (HEV) infections, either in acute or chronic forms of HEV infection in North-Eastern France, with liver- or non liver-related symptoms, plus data on HEV circulation in the outside environment. The purpose of this study is to improve the diagnosis and care of HEV-infected patients, as well as the preventive features to take into account in order to avoid food- and environment-borne infections. At last, we will investigate HEV molecular characteristics, with the hypothesis that some advantageous HEV strains coul be more pathogenic for some tissues and/or organs.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Hepatitis E Infection in Humans and in Environment

Interventions

Only advice for diagnosis and preventionOTHER

Only advice for diagnosis and prevention

Eligibility

Medical Language ↔ Plain English

Inclusion Criteria: * HEV-infected patients, with hepatitis and/or neurological and/or renal symptoms Exclusion Criteria: * Patients, with hepatitis and/or neurological and/or renal symptoms, infected by other viruses leading to hepatitis (hepatitis B, hepatitis C, hepatitis A ...)

Outcomes

Primary Outcomes

Anti-HEV IgM (qualitative assay);

Guidelines to improve HEV detection by using the 2 virological assays

Time frame: 2 years

HEV RNA (quantitative PCR assay)