The study purpose is to evaluate the morphological, functional and electrophysiological characteristics of the right ventricle before and after ajmaline in patients diagnosed with Brugada syndrome as well as to correlate CMR findings and substrate size.
All consecutive patients with either spontaneous or ajmaline-induced BrS-ECG pattern will be screened. A total of 30 BrS patients and 30 normal age, sex and BSA matched normal controls will be selected and enrolled. Patients will perform cardiac magnetic resonance imaging to evaluate and compare morphological and functional characteristics of the 2 groups before and after ajmaline. BrS patients will also perform a standardized programmed ventricular stimulation protocol and electroanatomical mapping to determine the substrate size.
Study Type
OBSERVATIONAL
Enrollment
60
Ajmaline 17-(Chloroacetate) Monohydrochloride(1mg/kg in 5 minutes)
IRCCS Policlinico S. Donato
San Donato Milanese, Milano, Italy
Electrocardiographic changes
Changes of PR, QRS, and QT parameters, before and after ajmaline in Brugada patients as compared with control subjects
Time frame: 1 day during Electrocardiography
MRI changes of left and right ventricular function
MRI changes of left and right ventricular function before and after ajmaline in Brugada patients as compared with control subjects
Time frame: 1day during MRI
CMR parameters changes of the right and left ventricle function
Changes of right ventricular areal strain before and after ajmaline in Brugada patients as compared with controls
Time frame: 1 day during CMR
Electrical substrate changes of the right ventricle
electroanatomical epicardial mapping for substrate determination before and after ajmaline
Time frame: 1 day after ICD implantation
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