The difficulty to measure blood flow in humans is connected with the necessity of using not invasive, reliable and reproducible techniques. There is several quantitative approaches to study eye blood flow which do not answer all these specifications. The laser doppler velocimetry allows movement speed measures but not vessel diameter. Optical coherence tomography doppler allows a simultaneous diameter and speed of travel (movement) measures, but presents a limited spatial resolution and thereby not easily reproducible vessel diameter measures. The investigators propose development of a technique allowing a simultaneous diameter and velocity measure of these vessels.
The eye blood flow plays a fundamental role in the eye physiology, insuring the metabolic contributions of various eye tissues, in particular those associated with the vision photochemical processes. Eye blood flow changes are involved in the physiopathology of several frequent eye diseases susceptible to lead to blindness (glaucoma,age-related macular degeneration, venous or arterial occlusions). Numerous systematic pathologies can also alter eye blood flow (diabetes, sleep apnea, arterial high blood pressure, inflammation). The difficulty to measure blood flow in humans is connected with the necessity of using not invasive, reliable and reproducible techniques. There is several quantitative approaches to study eye blood flow which do not answer all these specifications. The laser doppler velocimetry allows movement speed measures but not vessel diameter. Optical coherence tomography doppler allows a simultaneous diameter and speed of travel (movement) measures, but presents a limited spatial resolution and thereby not easily reproducible vessel diameter measures. The investigators propose development of a technique allowing a simultaneous diameter and velocity measure of these vessels.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
NONE
Enrollment
290
Fluxometry measure while subject is sitting in front of the optic adaptative camera
University Hospital Grenoble
Grenoble, France
RECRUITINGChange of total retinal blood flow in healthy subject
Total retinal blood flow measurement in healthy subject at rest
Time frame: Day 0, Day 30 to Day 60
Repeatability and reproducibility of retinal blood flow measures intra and inter session
Coefficient of variation for Repeatability and Reproducibility (3 measures session every 5 minutes on the same day, repeated one or two months after)
Time frame: Day 0, Day 30 to Day 60
Change of retinal blood flow in different ages subjects
Total retinal blood flow measurement in different ages subjects
Time frame: Day 0, Day 30 to Day 60
Evaluation of the relation between retinal blood flow and vessel diameter
Retinal blood flow and diameter of principal vessels coming from the optic disc
Time frame: Day 0, Day 30 to Day 60
Measure retinal blood flow in subject with glaucoma and compare results with healthy subjects
Total retinal blood flow measured in subjects with glaucoma and age- and sex-matched healthy subjects
Time frame: Day 0
Measure retinal blood flow in subject with retinal vein occlusion and compare results with measurements made in ipsilateral non pathogenic vessels, controlateral vessels and healthy subjects.
Total blood flow compare to the controlateral eye and healthy subject data
Time frame: Day 0, Month 1, Month 2, Month 3, Month 6
Retinal blood flow evaluation after 1, 2 and 3 months after the inclusion of subject with retinal vein occlusion
Partial retinal blood flow in a occluded temporal vein compare to a healthy ipsilateral temporal vein
Time frame: Day 0, Month 1, Month 2, Month 3
Retinal blood flow evaluation after 1, 2, 3 and 6 months after intravitreal injection of aflibercept in subject treated for macular oedema as a complication of retinal vein occlusion
Retinal blood flow evolution will be evaluated regarding macular oedema and retinal ischaemia occurence
Time frame: Day 0, Month 1, Month 2, Month 3, Month 6
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