Probe dietary intervention study in healthy young adult males to evaluate the concentration of apigenin derived metabolites in plasma and urine after single acute intakes of different apigenin-containing test materials.
Flavonoids, including the sub groups of Flavones (FO) are plant-derived compounds commonly present in the human diet. Examples of FO-containing foods and beverages are parsley, celery, and chamomile. The study described below will provide initial information of apigenin derived metabolites in humans. The investigators suggest the information that will be obtained from the outlined work will be particularly timely given increasing interest in the putative health effects of FO intake in humans. This study consisted of two parts. The first part consisted of a probe study in which the investigators investigated the absorption and metabolism from four flavone-containing test products. The second phase investigated absorption and metabolism after the intake of a flavone-containing parsley drink.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Enrollment
17
Chamomile Tea in 300mL hot water
3.2 g dried parsley in 300mL hot water
3.2 g dried parsley in 100g plain yogurt
Ragle Human Nutrition Research Center, Department of Nutrition at UC Davis
Davis, California, United States
UC Davis
Davis, California, United States
Flavone metabolites in plasma
Concentration of flavone metabolites in plasma
Time frame: before to 6 h post test material intake
Flavone metabolites in urine
Amount of flavone metabolites excreted in urine
Time frame: 12 h before to 24 h post test material intake
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Apigenin capsule mixed with 300mL hot water
3.2 g dried parsley in 300mL hot water