A Randomized Trial of Rosuvastatin Loading Combined With Early hydrAtion Versus Standard-of-care Medications for the Prevention of CIAKI in Patient With AMI Undergoing Emergency PCI

Inclusion Criteria: * Age 18-80 years old * The STEMI patients within 12 h of onset(or within 12-24 h of onset with chest pain and persistent ST-segment elevation or the presence of a new LBBB); * The patients planned primary PCI; * At least one of the following: Diabetes mellitus, Chronic Kidney Disease, Female, Elder(Age≥65), Hypertension class 3, Congestive heart failure • Voluntary signature of informed consent Exclusion Criteria: * Type 2 Myocardial infarction secondary to an ischaemic imbalance * Intolerance of statin or iodine contrast * eGFR\<30ml/min * Administration of any iodinated (e.g.CT angiography) within 14 days before enrollment * Hepatic dysfunction, ALT 3 times greater than upper normal limit * Thyreoid insufficiency * Hemodynamic instability * Have received PCI or CABG within 30 day before enrollment * Plan to perform any coronary angiography or PCI within 30 days * Have received any statins within 7 days before enrollment