Effect of Lactobacillus Rhamnosus on Serum Uremic Toxins in Hemodialysis

nooshin dalili42 enrolled

Overview

Uremic toxins such as p-cresol and phenol are suggested to be associated with higher mortality in hemodialysis patients. The aim of this study was to investigate the effects of probiotics on serum p-cresol level in hemodialysis patients.

Overall, 42 hemodialysis patients (10 women and 32 men) were divided randomly into the Lactobacillus rhamnosus group (21 patients) and the placebo group (21 patients).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Hemodialysis Complication

Interventions

Lactobacillus rhamnosusDIETARY_SUPPLEMENT

daily one capsule containing 1.6\*107 CFU of Lactobacillus Rhamnosus prepared by Tabriz Nutrition Research Center from yogurt and cheese of different farms located in the suburbs Heris, after meal for 28 days

Placebo - CapDRUG

daily one capsule of placebo

Eligibility

Sex: ALLMin age: 20 Years

Medical Language ↔ Plain English

Inclusion Criteria:• Age more than 20 years * Acceptable performance of alimentary system * Ability to drink at least 200 ml of water per day * No history of being allergic to fungi and yeast * Absence of acute medical illness * life expectancy more than 3 months * Accept and sign the consent Exclusion Criteria: * Patient's unwillingness to participate in the study * History of smoking, peritoneal dialysis (PD) or previous kidney transplantation * Lactation or pregnancy * Drug history including antibiotics, prebiotics, probiotics, herbal drugs, psychedelic drugs, flavors.

Outcomes

Primary Outcomes

pre- and post-treatment p-cresol levels

Time frame: 4 weeks

Data from ClinicalTrials.gov

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