Active Matrix Metalloproteinase-8 (aMMP-8) Chair-side Test in Different Periodontal Disease

Aydin Adnan Menderes University103 enrolled

Overview

The aim of this study to evaluate the diagnostic accuracy of a new qualitative aMMP-8 POC test in different periodontal health and disease and as compared to the established quantitative laboratory method (ELISA)

MMP-8 has been reported to reflect the inflammatory status in periodontal tissues and, therefore represent as potential biomarkers of periodontitis. A positive aMMP-8 test could be an early indicator of these excessive and undesired tissue reactions.

Study Type

OBSERVATIONAL

Enrollment

103

Conditions

Periodontal Diseases

Interventions

GCF collection with aMMP-8 chair side testDIAGNOSTIC_TEST

Saliva collectionOTHER

Eligibility

Sex: ALLMin age: 20 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Systemically healthy * Nonsmokers Exclusion Criteria: * Participants were not included if they had systemic disease such as diabetes, cardiovascular. * Participants who took regular medications that could affect of periodontal tissue * Participants who received antibiotics less than 10 weeks before the study

Outcomes

Primary Outcomes

aMMP-8 levels of GCF

GCF levels measured by IFMA

Time frame: 2 hours

Secondary Outcomes

Salivary MMP-8 levels

Saliva levels measured by IFMA

Time frame: 2 hours

Data from ClinicalTrials.gov

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