Endothelial dysfunction and vasoreactivity disorders are early subclinical complications of type 1 diabetes (T1D). In a preventive setting, in T1D patients still free of complications, the research of non-pharmacological interventions to improve endothelial function appears fundamental. In this randomized controlled trial, the effects of exercise training on endothelial function will be evaluated in T1D adults. Secondary objectives are to evaluate the exercise training effects on the micro and macrovascular function and exercise-induced tissue vasoreactivity and their possible neurometabolic consequences. An improvement in vascular function, particularly endothelium-dependent, as well as in neurometabolic profile, through this non-pharmacological strategy is expected
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Enrollment
34
Exercise training: 3 sessions - 2 supervised and 1 unsupervised - per week of 30-60 min at 65% - 80% of maximum heart rate (4 months)
No supervised exercise training during the 4 month period.
Hop Claude Huriez Chu Lille
Lille, France
RECRUITINGChange in percent flow-mediated dilation (FMD) values
Time frame: between baseline and at 4 months
Change the vascular responses
Endothelium-dependent vasodilation capacity induced by post-occlusive reactive hyperaemia (5min occlusion) at the level of microcirculation (skin capillaries and arterioles of the hand) -Vasoreactivity of the cutaneous capillaries of the forearm in response to acetylcholine and sodium nitroprusside (iontophoresis)
Time frame: at baseline , at 2 months , at 4 months
Change the vascular responses
Endothelium-dependent vasodilation capacity induced by post-occlusive reactive hyperaemia (5min occlusion) at the level of microcirculation (skin capillaries and arterioles of the hand) -Dilatatory macrocirculation (brachial artery) and microcirculatory (capillaries of the hand) to nitroglycerine (in sublingual spraying)
Time frame: at baseline , at 2 months , at 4 months
Change the vascular responses
Endothelium-dependent vasodilation capacity induced by post-occlusive reactive hyperaemia (5min occlusion) at the level of microcirculation (skin capillaries and arterioles of the hand) -Evolution of the blood volume at the vastus lateralis muscle and the prefrontal cortex in response to an incremental maximal exercise
Time frame: at baseline , at 2 months , at 4 months
Change in percent flow-mediated dilation (FMD) values
Time frame: between baseline and at 2 months
change the maximum oxygen consumption ( VO2max)
Time frame: at baseline , at 2 months , at 4 months
Change Blood marker concentrations of nitric oxide (NO)
Time frame: at baseline , at 2 months , at 4 months
change Blood concentration of neurotrophic factors
Blood concentration of neurotrophic factors and blood markers of metabolic profile
Time frame: at baseline , at 2 months , at 4 months
Body composition (DEXA)
Time frame: at baseline , at 2 months , at 4 months
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