This study investigates the effect of detailed, written dietary advice for improving blood lipids, in a primary care setting. n=222 participants will be randomized to Active Intervention or Control Group. After 3 weeks' intervention, participants will receive written feedback on the effect on their blood lipids. After 6 months, another blood sample is drawn and participants will receive further written feedback.
The Active Intervention Group will receive detailed dietary advice based on current evidence for food choices that improve LDL cholesterol levels. The information will contain motivational strategies, e.g. "It's great that you want to improve your blood lipids! What are your three main reasons that you want to improve your blood lipids? What food choices suit you? How low can you go?" Participants will receive a table of ten suggested healthy food choices and be instructed to mark for each day a certain food change has been made. The Control Group will receive similar advice and motivational strategies, with the one difference being the dietary advice, that will focus on Triglycerides instead of LDL cholesterol.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
113
One A4 paper with written information on both sides
One A4 paper with written information on both sides
Svärdsjö Primary Health Care Centre
Falun, Dalarna County, Sweden
LDL Cholesterol
Change in plasma LDL Cholesterol levels
Time frame: 3 weeks and 6 months
Total Cholesterol
Change in plasma Total Cholesterol levels
Time frame: 3 weeks and 6 months
HDL Cholesterol
Change in plasma HDL Cholesterol levels
Time frame: 3 weeks and 6 months
Apolipoproteins
Change in plasma Apolipoprotein levels
Time frame: 3 weeks and 6 months
Success rate
Percentage of participants that reduce LDL Cholesterol at least 10%
Time frame: 3 weeks and 6 months
Responder effect
Change in plasma LDL cholesterol after 6 months in participants that reduce LDL Cholesterol at least 10% at 3 weeks
Time frame: 6 months and 3 weeks, respectively
Double sampling requirement
Number of participants that would have been misclassified if not double sampling hade been performed for LDL cholesterol
Time frame: 3 weeks and 6 months
Cost of intervention
Cost of intervention, in comparison to possible health gains
Time frame: 3 weeks and 6 months
Effective food choices
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Food choices that are in practice effective for lowering LDL cholesterol
Time frame: 3 weeks and 6 months
Stated reasons
Stated reasons for wanting to improve blood lipid profile and associations with effect on LDL Cholesterol
Time frame: 3 weeks and 6 months
PSCK9
Change in serum PCSK9 levels
Time frame: 3 weeks and 6 months
Lipoprotein(a)
Change in plasma lipoprotein(a) levels
Time frame: 3 weeks and 6 months