Pilot Study to Evaluate the Safety and the Efficacy of the Matrix and Cells Obtained by the AmeaCell® Device and Intended for the Filling of Wrinkles on the Face.

Inclusion Criteria: * Man or woman from 18 to 70 years * Subject wishing liposuction * Subject wishing a filling of facial wrinkles for aesthetic purposes * Subject for which it is possible to achieve a puncture of adipose tissue of at least 150ml so that after decantation or centrifugation there remains 100ml of adipose tissue * Facial wrinkles that can be treated with the Matrix and Cells volume of approximately 12ml * Grade of wrinkles at level 2 minimum of the nasolabial fold according to the WSRS scale * Free, informed and written consent * Affiliate or beneficiary of a social security scheme Exclusion Criteria: * Pregnant or breastfeeding woman or planning to be pregnant * Woman of childbearing age without effective contraceptive * Subject having a filling of facial wrinkles with hyaluronic acid or by a method of lipofilling (injection of adipose tissue) in the 12 months prior to the enrollment * Subject who has undergone treatment of facial wrinkles by injection of botulinum toxin, by mesotherapy or cosmetic procedure (laser, photo modulation, intense pulsed light, radio frequency, dermabrasion, chemical peel or other ablative procedures) within 12 months at least prior to enrolment or subject who is planning this type of procedure during the study * Subject who has received semi-permanent dermal fillers or permanent facial implants or who is planning to do this type of implant during the study * Subject having history of formation of hypertrophic scars or keloids * Subject having a skin disease or skin inflammation (e.g. acne, herpes, eczema, psoriasis, sclerosis) at the site to be treated or elsewhere on the body if suspected of spreading on the site to be treated * Subject with allergic contact dermatitis or a history of allergic contact dermatitis or a family history of allergic contact dermatitis * Presence of tattoo and / or scar in the treatment area that, in the opinion of the investigator, could interfere with the evaluation of the study * Diabetes (type I or type II) * Human Immunodeficiency Virus (HIV), Hepatitis B Virus (HBV) or Hepatitis C Virus (HCV) seropositivity * Subject under anti-HIV treatment * Autoimmune disease * Immunodepression * History of phlebitis or pulmonary embolism * Major pathology involving the renal, hepatic, cardiovascular, immune and / or nervous system * Cancerous lesion on the face * Any other diseases that could, in the opinion of the investigator, be clinically significant and make the subject inappropriate for the study, alter the results of the study or increase the risk for the subject * Known hypersensitivity to cobalt * Known hypersensitivity to collagenase * Known or suspected allergy to lidocaine or any other amide anesthetic * History of known severe allergies (anaphylaxis, angioedema) for a product used in the study * Any contraindication to lipofilling surgery * Active smoking or subject who stopped smoking less than one month before the intervention * Radiotherapy treatment at the head and neck region. * Chemotherapy treatment * Treatment with anticoagulant or Nonsteroidal anti-inflammatory drug (NSAID) or any other substance known to increase clotting time during the 2 weeks prior to enrollment * Corticosteroids in the 6 weeks prior to enrollment * Subject having a metal-metal hip prosthesis * Subject under lidocaine or structurally related local anesthetic (e.g. bupivacaine) within 24 hours prior to enrollment * Subject having undergone general anesthesia for less than 8 days * Treatment with an oral or topical retinoid in the month prior to enrollment * Subject having a history of drug or alcohol addiction in the 12 months prior to enrollment * Participation in another research including an exclusion period still in progress at the time of enrollment * Person placed under guardianship or curatorship or under the protection of justice