NCT03529643 - Effect of Anesthetic Method on Optic Nerve Sheath Diameter in Patients Undergoing RALP | Crick

Overview

The purpose of this study was to evaluate the effect of anesthetic method on the optic nerve sheath diameter in patients undergoing robot-assisted laparoscopic prostatectomy.

The purpose of this study was to evaluate the difference between the optic nerve sheath diameter measured during anesthesia with sevoflurane-remifentanil-dexmedetomidine and the optic nerve sheath diameter measured during anesthesia with sevoflurane-remifentanil in patients undergoing robot-assisted laparoscopic prostatectomy.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

QUADRUPLE

Enrollment

128

Conditions

Prostate Cancer

Interventions

DexmedetomidineDRUG

Anesthesia with sevoflurane-remifentanil-dexmedetomidine

Without dexmedetomidineOTHER

Anesthesia with sevoflurane-remifentanil

Eligibility

Sex: MALEMin age: 20 YearsMax age: 79 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Undergone a robot-assisted laparoscopic prostatectomy with a prostate - cancer * 20 years of age or older and under 80 years of age * Agree to participate in this study Exclusion Criteria: * History of cerebral hemorrhage or cerebral infarction * \< 20 years of age * ≥ 80 years of age * Glaucoma * Unexpected hemodynamic instability during surgery * Failure to measure optic nerve sheath diameter * Convert to open surgery

Locations (1)

Asan medical Center

Seoul, South Korea

Outcomes

Primary Outcomes

Difference in optic nerve sheath diameter

Difference between the optic nerve sheath diameter measured during anesthesia with sevoflurane-remifentanil-dexmedetomidine and the optic nerve sheath diameter measured during anesthesia with sevoflurane-remifentanil in patients undergoing robot-assisted laparoscopic prostatectomy

Time frame: 60 minutes after pneumoperitoneum and steep Trendelenburg position

Secondary Outcomes

Difference in optic nerve sheath diameter

Difference between the optic nerve sheath diameter measured during anesthesia with sevoflurane-remifentanil-dexmedetomidine and the optic nerve sheath diameter measured during anesthesia with sevoflurane-remifentanil in patients undergoing robot-assisted laparoscopic prostatectomy.

Time frame: 30 minutes after pneumoperitoneum and steep Trendelenburg position

Difference in optic nerve sheath diameter

Difference between the optic nerve sheath diameter measured during anesthesia with sevoflurane-remifentanil-dexmedetomidine and the optic nerve sheath diameter measured during anesthesia with sevoflurane-remifentanil in patients undergoing robot-assisted laparoscopic prostatectomy

Time frame: 10 minutes after anesthesia induction

Difference in optic nerve sheath diameter

Difference between the optic nerve sheath diameter measured during anesthesia with sevoflurane-remifentanil-dexmedetomidine and the optic nerve sheath diameter measured during anesthesia with sevoflurane-remifentanil in patients undergoing robot-assisted laparoscopic prostatectomy

Time frame: At skin closure