Work of Breathing and Oxygen Saturation in Infants Receiving High Flow Nasal Cannula (HFNC)

Christiana Care Health Services30 enrolled

Overview

The purpose of this study is to compare work of breathing on different levels of high flow respiratory support on infants born between 27 and 37 weeks gestation.

Study Type

OBSERVATIONAL

Enrollment

Conditions

High Flow Nasal Cannula

Interventions

EnrollmentOTHER

All infants enrolled will have work of breathing assessed.

Eligibility

Sex: ALLMax age: 6 MonthsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Infants between 27 and 37 weeks corrected gestational age * \>4 days PNA * Stable (i.e. not meeting exclusion criteria) and receiving non-invasive respiratory support (HFNC) for ≥ 12 hours * Requiring ≤ 40% supplemental FiO2 as determined by the clinical care team for clinical care purposes independent of this study Exclusion Criteria: * Infants with skeletal, neuromuscular, or abdominal surgical disorders that affect the accuracy of WOB measurements

Locations (1)

Christiana Care Health Services, Inc.

Newark, Delaware, United States

Outcomes

Primary Outcomes

Work of breathing indices

Altering HFNC flow rates and its effect on work of breathing indices in preterm infants with respiratory insufficiency.

Time frame: 2 hours

Secondary Outcomes

Intermittent hypoxia

Altering HFNC flow rates and its effect on intermittent hypoxia in preterm infants with respiratory insufficiency.

Time frame: 2 hours

Data from ClinicalTrials.gov

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