Drug-drug Interaction Between Belumosudil, Itraconazole, Rifampicin, Rabeprazole, and Omeprazole in Healthy Volunteers

Inclusion Criteria: 1. Healthy males 2. Age 18 to 55 years 3. Good state of health (mentally and physically) as indicated by a comprehensive clinical assessment (detailed medical history and a complete physical examination), electrocardiogram (ECG) and laboratory investigations (hematology, clinical chemistry, and urinalysis) 4. Body weight ≥50 kg 5. Body mass index of 18.0 to 32.0 kg/m\^2 or, if outside the range, considered not clinically significant by the investigator 6. Must be willing and able to communicate and participate in the whole study 7. Must provide written informed consent 8. Must adhere to the contraception requirements Exclusion Criteria: 1. Subjects who had previously participated in any other investigational study drug trial in which receipt of an IP occurred within 90 days prior to dosing. (Subjects who had previously received belumosudil in Part 1 at least 90 days prior to dosing in Part 2 were eligible to participate.) 2. Subjects who are study site employees, or immediate family members of a study site or sponsor employee 3. Subjects with pregnant partners 4. History of any drug or alcohol abuse in the past 2 years 5. Regular alcohol consumption in males \>21 units per week (1 unit = ½ pint beer, or a 25 mL shot of 40% spirit, 1.5 to 2 units = 125 mL glass of wine, depending on type) 6. Current smokers and those who have smoked within the last 12 months. A breath carbon monoxide reading of greater than 10 ppm at screening and admission 7. Current users of e-cigarettes and nicotine replacement products and those who have used these products within the last 12 months 8. Subjects who do not have suitable veins for multiple venepunctures/cannulation as assessed by the investigator at screening 9. Clinically significant abnormal biochemistry, haematology or urinalysis as judged by the investigator 10. Positive drugs of abuse test result at screening and admission 11. Positive hepatitis B surface antigen (HBsAg), hepatitis C virus antibody (HCV Ab) or human immunodeficiency virus (HIV) results 12. Evidence of renal impairment at screening, as indicated by an estimated creatinine clearance (CLcr) of \<80 mL/min using the Cockcroft-Gault equation 13. History of clinically significant cardiovascular, renal, hepatic, chronic respiratory or gastrointestinal disease, neurological or psychiatric disorder, as judged by the investigator 14. Subject has a history or presence of any of the following: * Active gastrointestinal disease requiring therapy * Hepatic disease and/or alanine aminotransaminase (ALT) or aspartate aminotransaminase (AST) \> ULN * Renal disease and/or serum creatinine \> ULN * Other condition known to interfere with the absorption, distribution, metabolism or excretion of drugs 15. Subjects with a history of cholecystectomy or gall stones 16. Subject has QT interval corrected using Fridericia's formula (QTcF) intervals \>450 msec at screening or admission 17. Serious adverse reaction or serious hypersensitivity to any drug or the formulation excipients; including intolerance to itraconazole, rabeprazole, and rifampicin 18. Presence or history of clinically significant allergy requiring treatment, as judged by the investigator. Hayfever is allowed unless it is active 19. Donation or loss of greater than 400 mL of blood within the previous 3 months 20. Subjects who are taking, or have taken, any prescribed or over-the-counter drug (other than 4 g per day paracetamol) or herbal remedies in the 14 days before IP administration. 21. Failure to satisfy the investigator of fitness to participate for any other reason Subjects Agreed to the Following Restrictions During the Duration of the Study: 1. No alcohol during the 24-hour period prior to screening and the 24-hour period prior to admission in Period 1, and 24 hours prior to commencing non-IP treatment in Part 1, Periods 2 to 4 and Part 2, Period 2, until discharge for each treatment period. 2. No food or drinks containing grapefruit or cranberry from 24 hours prior to admission in Period 1, and 24 hours prior to commencing non-IP treatment in Part 1 Periods 2 to 4 and Part 2 Period 2, until discharge for each treatment period. 3. No food or drinks containing caffeine or other xanthines from 24 hours prior to admission until discharge for each treatment period. 4. No food containing poppy seeds for 48 hours prior to screening and for 24 hours prior to admission until discharge for each treatment period. 5. No unaccustomed or strenuous exercise from the 72-hour period before the screening visit and then from 24 hours prior to admission until discharge for each treatment period.