Chronic plaque psoriasis is frequently associated with obesity and previous studies have shown that a calorie-controlled diet inducing body weight loss improves symptoms and increases the response to pharmacologic treatment. Besides, clinical improvement has been directly correlated with the amount of weight loss. Short-term very low-calorie ketogenic diets are responsible for substantial weight loss and attenuate systemic inflammation to a higher extent than moderately hypocaloric diets. This intervention has been recently demonstrated to restore, after only 4 week, the response to biological therapy in a patient suffering from relapsing moderate-to-severe plaque psoriasis and obesity-related metabolic syndrome. We investigated the efficacy of an aggressive weight loss program with a ketogenic induction phase in a single-arm trial that could provide the rationale for a large randomized trial.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
37
A 4-week protein-sparing, very low-calorie, ketogenic diet and a subsequent 6-week hypocaloric, low glycemic index, Mediterranean-like diet
A.O.R.N. "San Giuseppe Moscati"
Avellino, Italy
Reduction in Psoriasis Area and Severity Index
Change in score (on continuous scale) at the end of study
Time frame: 10 weeks
Reduction in Psoriasis Area and Severity Index
Change in score (on continuous scale) at the end of ketogenic diet-phase
Time frame: 4 weeks
Reduction in Psoriasis Area and Severity Index >=75%
Proportion of patients with change in score \>=75% at the end of study
Time frame: 10 weeks
Reduction in Psoriasis Area and Severity Index >=75%
Proportion of patients with change in score \>=75% at the end of ketogenic diet-phase
Time frame: 4 weeks
Reduction in Psoriasis Area and Severity Index >=50%
Proportion of patients with change in score \>=50% at the end of study
Time frame: 10 weeks
Reduction in Psoriasis Area and Severity Index >=50%
Proportion of patients with change in score \>=50% at the end of ketogenic diet-phase
Time frame: 4 weeks
Reduction in body surface area
Change in body surface area (on continuous scale) involved at the end of study
Time frame: 10 weeks
Reduction in body surface area
Change in body surface area (on continuous scale) involved at the end of ketogenic diet-phase
Time frame: 4 weeks
Reduction in Dermatology Life Quality Index (DLQI)
Change in DLQI (on continuous scale) at the end of study
Time frame: 10 weeks
Reduction in Dermatology Life Quality Index (DLQI)
Change in DLQI (on continuous scale) at the end of ketogenic diet-phase
Time frame: 4 weeks
Reduction in itch severity
Change in itch severity (on continuous visual analogue scale) at the end of study
Time frame: 10 weeks
Reduction in itch severity
Change in itch severity (on continuous visual analogue scale) at the end of ketogenic diet-phase
Time frame: 4 weeks
Reduction in body weight
Change in body weight (on continuous scale) at the end of study
Time frame: 10 weeks
Reduction in body weight
Change in body weight (on continuous scale) at the end of ketogenic diet-phase
Time frame: 4 weeks
Reduction in Visceral fat
Change in aorto-mesenteric fat thickness (on continuous scale) at the end of study
Time frame: 10 weeks
Reduction in Visceral fat
Change in aorto-mesenteric fat thickness (on continuous scale) at the end of ketogenic diet-phase
Time frame: 4 weeks
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.