Alzer® and Diamel® to Prevent Severe Diabetes Macular Edema

Inclusion Criteria: * Diabetics type 2 insulin treated. * Age between 18 and 65 years. * Glycosylated hemoglobin (HB A1c) \<8% at the beginning of the investigation. * Patients who express written voluntariness to enter the study with their signature of the informed consent document. * If woman of childbearing age, negative pregnancy test and use of barrier contraceptives. Exclusion Criteria: * Pregnancy and lactation. * Age over 65 years. * Macular edema with vitreous-retinal traction or other cause (renal, arterial hypertension, post-surgical). * Opacity of the refractive media that hinders the ophthalmological examination. * History of hypersensitivity to another similar product or one of its components. * Patients at potential risk of not compliance the study (those who will travel during the period of the investigation or distance in their residence, outside the city). * Subjects who are participating in another clinical trial Patients with cognitive disorders or a mental disorder that hinders their follow-up.