Indomethacin Prior to Difficult Embryo Transfer is it a Solution?

Cairo University200 enrolled

Overview

IVF/ICSI patients who had difficult mock embryo transfer on the day of ovum pick up. Will be randomly assigned into two groups; group A will receive 100mg indomethacin rectal suppository 1-2 hours before ET and group B will not receive indomethacin

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

200

Conditions

Difficult Embryo Transfer

Interventions

Indomethacin 100Mg SuppositoryDRUG

Indomethacin 100Mg Suppository will be given 1 to 2 hours before embryo transfer in cases with difficult mock embryo transfer in the active comparator group.

IVF/ICSIPROCEDURE

patients received induction with the long agonist stimulation protocol. Followed by ovum pickup and embryo transfer. Only those with difficult mock embryo transfer will be recruited in this study.

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 38 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Infertile patients undergoing IVF cycle with difficult mock embryo transfer * Early follicular FSH level ≤10 IU/L. * Tubal, male infertility and unexplained causes of fertility will be recruited. * Fresh ET. Exclusion Criteria: * Repeated IVF failure. * Past history of allergy to NSAID, bronchial asthma , peptic ulcer or inflammatory bowel disease. * Easy mock embryo transfer.

Locations (1)

Nile IVF center

Giza, Egypt

Outcomes

Primary Outcomes

Implantation rate

the number of total gestational sacs divided by the total number of embryos transferred.

Time frame: 6 weeks

Secondary Outcomes

Clinical pregnancy rate

Presence of fetal pulsations after 2 weeks from the positive pregnancy test.

Time frame: 6 weeks

Ongoing pregnancy rate

Pregnancies continuing beyond 12 weeks

Time frame: 12 weeks

Data from ClinicalTrials.gov

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