Metabolic syndrome is a condition which is recognized by abdominal obesity, dyslipidemia, hyperglycemia, and hypertension. Curcumin has beneficial effects such as antioxidant and anti-inflammatory effects. nanomcielle curcumin will be used in this study because of the low bioavailability , fast metabolism and low absorption of curcumin powder. Therefore, this study is planned to determine the effects of supplementation of nanomicelle curcumin on glycemic control, serum lipid profile ,blood pressure and anthropometric measurements in patients with metabolic syndrome.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
DOUBLE
Enrollment
50
Participants will be selected from those referring to endocrinology clinics of Shohadaye YaftAbad and Pars Hospital (Tehran, Iran) who meet the inclusion criteria. Each subject will give informed written consent to participate in the study. 10 cc fasting blood samples will be collected from each subject at baseline and at the end of trial. Anthropometric parameters will be measured.In order to control the confounding factors in patients, they will be randomly assigned to receive either nanomicelle curcumin or placebo. nanomcelle curcumin and placebo supplements will be provided from the Elixir Nano Sina Company the patients will advise not to change their lifestyle during the study.
Participants will be selected from those referring to endocrinology clinics of Shohadaye YaftAbad and Pars Hospital (Tehran, Iran) who meet the inclusion criteria. Each subject will give informed written consent to participate in the study. 10 cc fasting blood samples will be collected from each subject at baseline and at the end of trial. Anthropometric parameters will be measured.In order to control the confounding factors in patients, they will be randomly assigned to receive either nanomcielle curcumin or placebo. nanomcelle curcumin and placebo supplements will be provided from the Elixir Nano Sina Company the patients will advise not to change their lifestyle during the study.
Golbon Sohrab
Tehran, National Nutrition and Food Technology Research Institute, Iran
RECRUITINGhemoglobin A1c (HbA1c)
Time frame: 12 weeks
serum glucose
Time frame: 12weeks
serum insulin
Time frame: 12weeks
homeostatic model assessment of insulin resistance(HOMA-IR)
Time frame: 12weeks
homeostatic model assessment of beta cell(HOMA-B)
Time frame: 12weeks
serum triglyceride (TG)
Time frame: 12 weeks
serum total Cholesterol
Time frame: 12 weeks
serum LDL-C
Time frame: 12 weeks
serum HDL-C
Time frame: 12 weeks
systolic blood pressure
Time frame: 12 weeks
diastolic blood pressure
Time frame: 12 weeks
serum curcumin
Time frame: 12 weeks
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