A multi-center,randomized,double-blind,controlled clinical trial was used to investigate the effectiveness of the treatment of infant iron deficiency anemia by taking ferralia and different contents lactoferrin.
5-9 months old infants with iron deficiency anemia were randomly divided into three groups. On the basis of giving the same dose of ferralia,three different levels lactoferrin infant formula were intervened 3 months respectively,and evaluate the clinical effect.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
QUADRUPLE
Enrollment
135
Infants with iron deficiency anemia randomly divided into this group were given the same dose of ferralia with other groups,and were fed with infant formula without lactoferrin supplementation.
Infants with iron deficiency anemia randomly divided into this group were given the same dose of ferralia with other groups,and were fed with infant formula supplemented with low level of lactoferrin (38mg/100g).
Infants with iron deficiency anemia randomly divided into this group were given the same dose of ferralia with other groups,and were fed with infant formula middle supplemented with high level of lactoferrin (76mg/100g).
Chengdu Women's and Children's Central Hospital
Chengdu, China
Changes of Hb concentration(g/L)
Hb was measured by the hemoglobincyanide method
Time frame: Change of Hb concentration from baseline at 1 month and 3 months.
Change of body weight (kilograms)
Body weight is detected by electronic scale
Time frame: Changes of body weight from baseline at 1 month and 3 months.
Change of body length (meters)
Body length is detected by infant height bed
Time frame: Changes of body weight from baseline at 1 month and 3 months.
Change of head circumference (millimeters)
Head circumference detected by measuring tape
Time frame: Changes of body weight from baseline at 1 month and 3 months.
Change of serum ferritin concentration (μg/L)
concentrations of serum ferritin (SF,μg/L) were measured using a commercial enzyme-linked immunosorbent assay (ELISA; Sunbiote, Shanghai, China).
Time frame: Changes of serum iron concentration from baseline at 3 months.
Change of serum transferrin receptor concentration(mg/L)
Serum soluble transferrin receptor (sTfR, mg/L) was measured by microparticle-enhanced immunoassay (Sunbiote, Shanghai, China)
Time frame: Changes of serum transferrin receptor concentration from baseline at 3 months.
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.