Nonalcoholic Fatty Liver Disease and Cardiovascular Disease: the Correlation Analysis and Risk Prediction Model Study

Wuhan University5,000,000 enrolled

Overview

Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in the world. NAFLD is associated with a lot of comorbidity, such as diabetes, metabolic syndrome, coronary heart disease and chronic kidney diseases. However, the correlation between the NAFLD and cardiovascular disease (CVD) events remains controversial. This study is an observational study based on a big retrospective cohort in china to explore the prevalence of NAFLD in China, the risk factors associated with NAFLD, as well as whether patients with NAFLD are more prone to experience CVDs and CVD events.

Study Type

OBSERVATIONAL

Enrollment

5,000,000

Conditions

NAFLD Cardiovascular Diseases

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * males or females aged 18-75 Exclusion Criteria: * malignancy except primary liver cancer * pregnancy or breastfeeding * liver diseases of other etiology including hepatitis C virus infection ,autoimmune hepatitis,Wilson's disease,hemachromatosis,drug-induced hepatitis,parenteral nutrition * excessive alcohol consumption * cases missing crucial data

Locations (1)

Outcomes

Primary Outcomes

the prevalence of NAFLD in China

Time frame: June，2020

Secondary Outcomes

the risk factors associated with NAFLD

Time frame: August，2020

to indicate the prevalence of CVDs and CVD events in people with and without NAFLD

Time frame: October，2020