Prognostic Significance of Fatty Liver Disease in Bariatric Patients

Number of participant who will experience progressive fatty liver disease in case and control group

Difference NAFLD severity between case and control group after 10 years follow up. Simple steatosis is the mildest form and liver cirrhosis is the most serious manifestation: 1. Grade 1 steatosis 2. Grade 2 steatosis 3. Grade 3 steatosis 4. Non alcoholic steatohepatitis 5. Presence of fibrosis Kleiner grade 1-2 6. Presence of fibrosis Kleiner grade 3 7. Presence of liver cirrhosis

Time frame: 10 years follow up after inclusion

Change in continuous reaction time measurement after bariatric surgery

Continuous reaction time measurement will measure reaction time instability and is a measure of metabolic encephalopathy. The method is a 10-minutes, computerised registration of a series of motor reaction times to an auditory stimulus, with results reported as the CRTindex (50 percentile/(90-10) percentile) as a parameter of reaction time variability. A CRT index below 1.9 i considerede abnormal a may be a sign of hepatic encephalopathy.

Time frame: 10 years follow up after inclusion

Change in EEG after bariatric surgery

Change in mean dominant frequency(MD) on EEG spectral analysis. EEG disturbances in hepatic encephalopathy are (rated by severity)but there is no enough space here to describe it.

Time frame: 24 months after surgery

Change in intelligence quotient after bariatric surgery

Measured by Weschlers adult intelligence scale (WAIS). An IQ if 100 i the norm. Range 50-150.

Time frame: 24 months efter surgery