To determine the maintenance dose of vitamin D supplementation required for children with epilepsy to maintain normal vitamin D level.
children aged 2-16 years diagnosed with idiopathic epilepsy will be randomized to receive either cholecalciferol doses (400IU vs 1000IU) with follow up at 3 and 6 months post supplementation.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
116
oral drops
Reem ALKhalifah
Riyadh, Saudi Arabia
Vitamin D level < 75 nmol/L
Time frame: 6 months of supplementation
Seizure rate
Time frame: 6 months of supplementation
bone mineral density (BMD) measurement
Time frame: 6 months of supplementation
Cost- effectiveness of vitamin D supplementation
cost of vitamin D supplementation compared to the cost of poor bone health, hospital admission
Time frame: 6 months of supplementation
Safety: Prevalence of hypercalcemia total calcium >2.7mg/dl, 25 OH vit D level> 250 nmol/l, and Urine calcium: creatinine ration > 1.2 mol/mol, or > 0.41g/g.
Time frame: 6 months of supplementation
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