A high intake of fish is associated with positive health effects, including prevention and treatment of chronic non-communicable diseases, such as cardiovascular diseases (CVDs) and type 2 diabetes. These health effects have traditionally been attributed to the omega-3 fatty acids in fatty fish, but recent studies have suggested that also fish proteins may improve biomarkers of metabolic disease. Intake of cod fillet have previously shown beneficial effects on blood lipids, glucose regulation and body composition in adults with overweight or obesity. Health effect of cod residual material from fillet production (i.e., head, backbone, skin, cutoffs and entrails) have so far not been investigated, but residuals from other fish species have shown promising effects on glucose regulation in rats. The main aim of the current study is to investigate the effects of protein from cod fillet and cod residuals on serum lipids, glucose regulation and inflammatory markers in healthy overweight or obese adults.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
100
Intact cod protein from fillet 8 g protein daily for 8 weeks
Intact cod protein from residual material, 8 g protein daily for 8 weeks
Control group receive tablet containing fillers
Oddrun Anita Gudbrandsen
Bergen, Norway
Biomarkers related to lipid metabolism
Lipids will be measured in fasting serum samples
Time frame: 8 weeks
Biomarkers related to glucose regulation
Glucose, insulin and GLP-1 and will be measured in serum/plasma sampled in fasting and postprandial conditions.
Time frame: 8 weeks
Inflammatory markers
Cytokines will be measured in fasting serum/plasma
Time frame: 8 weeks
Body composition
Percent body fat will be measured using bioimpedance
Time frame: 8 weeks
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