The Comparison of Changes of QTc, Tp-e Interval, and Tp-e/QT Ratio, Tp-e/QTc Ratio on the ECG During Robotic-assisted Laparoscopic Radical Prostatectomy Under Sevoflurane, Desflurane and Total Intravenous Anesthesia -Randomized Controlled Trial

Yonsei University69 enrolled

Overview

The purpose of this study is to compare the changes of QTc, Tp-e interval, and Tp-e/QT ratio, Tp-e/QTc ratio on the ECG during robotic-assisted laparoscopic radical prostatectomy under sevoflurane, desflurane and total intravenous anesthesia

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

Conditions

Robotic-assisted Laparoscopic Radical Prostatectomy

Interventions

sevofluraneDRUG

anesthesia was induced with propofol (1.5 mg/kg) and target controlled infusion (TCI) of remifentanil (2-3 ng/mL of targeted effect site concentration (Ce). After intubation, inspired concentration of sevoflurane (0.8-1 MAC) and the Ce of remifentanil TCI (1.0-2.0 ng/ml) were adjusted to a BIS target level for hypnosis of 40-60 during surgery.

desfluraneDRUG

anesthesia was induced with propofol (1.5 mg/kg) and target controlled infusion (TCI) of remifentanil (2-3 ng/mL of targeted effect site concentration (Ce). After intubation, inspired concentration of desflurane (0.8-1 MAC) and the Ce of remifentanil TCI (1.0-2.0 ng/ml) were adjusted to a BIS target level for hypnosis of 40-60 during surgery.

propofol and remifentanilDRUG

anesthesia was induced with an effect-site concentration of 3-4 μg/ml propofol and 2-3 ng/ml remifentanil using target-controlled infusion (TCI). After intubation, The effect site TCI of propofol (2-3 μg/ml) and remifentanil (1.0-2.0 ng/ml) was adjusted to maintain the desired hypnosis (40-60 of the BIS value) during surgery.

Eligibility

Sex: MALEMin age: 19 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. ASA class I-III 2. patients undergoing elective robot-assisted laparoscopic radical prostatectomy 3. adult (≥19 years old) Exclusion Criteria: 1. emergency surgery 2. preoperative QTc prolongation 3. Cardiac disease (unstable angina, congestive heart failure, valvular heart disease) 4. uncontrolled hypertension (DBP \>110 mmHg) 5. Patients who take beta blocker 6. Ventricular conduction abnormality 7. Hepatic or renal failure 8. Drug hyperactivity 9. patients unable to understand informed consent (foreigner, illiteracy..)

Locations (1)

Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine

Seoul, Korea, South Korea

Outcomes

Primary Outcomes

heart-rate corrected QT(QTc) interval

QTc intervals (msec) are recorded from ECG

Time frame: participants will be followed for the duration of surgery, an expected average of 4 hours.