This will be a prospective study on labor characteristics, and obstetric and neonatal outcomes in women who accept and women who decline morphine as a form of pain management in labor. The study will also investigate patient satisfaction with this form of analgesia. The participants will be those who accept morphine and promethazine and those who decline morphine and promethazine for pain control.
Objective: Therapeutic rest in labor involves administration of parenteral analgesics in early or prodromal labor to relieve the patient's discomfort and allow for progression of labor while the patient rests. No prospective studies exist which examine the safety and clinical utility of therapeutic rest in early labor, and no published studies examine the potential benefits of therapeutic rest from the perspective of either patient satisfaction or cost-effectiveness. The investigators aim to determine whether therapeutic rest using morphine and promethazine is associated with variations in labor characteristics, or obstetric or neonatal outcomes as well as patient satisfaction with this form of pain management. Methods: This will be a prospective cohort study. Women who are eligible for therapeutic rest (reactive non-stress test, normal amniotic fluid, in prodromal or early labor as defined by obstetric provider, and plan to discharge home after evaluation) will be recruited for the study. Participants will receive routine obstetric care by providers who are unaware of patient enrollment. A research assistant will then approach all participants in the postpartum period, prior to discharge from the hospital or with a phone call if permitted by the patient, to complete a questionnaire including patient satisfaction items. Chart review will be performed to determine differences in hospital stay and common obstetric and neonatal outcomes to compare these data among women who do and do not choose to receive therapeutic rest. These results will provide insight into a common clinical practice, helping to not only guide management at institutions where therapeutic rest is commonly utilized but also potentially encourage its initiation at hospitals were therapeutic rest is not available.
Study Type
OBSERVATIONAL
Enrollment
82
Morphine sulfate and promethazine
UCSF Medical Center at Mission Bay
San Francisco, California, United States
The proportion of women who were admitted in active labor (6 cm or greater cervical dilation).
Admission in active labor
Time frame: 0 hours to 2 weeks
Time in hours between the start of contractions to being offered therapeutic rest
Duration of contractions in hours before presenting for rule out labor
Time frame: 1-2 weeks after delivery
Time in hours between being offered therapeutic rest and admission to labor and delivery
Latency period between being offered therapeutic rest and admission
Time frame: 1-2 weeks after delivery
Time in hours between admission to labor and delivery and complete cervical dilation
Length of admission
Time frame: 1-2 weeks after delivery
Time in hours between admission to labor and delivery and birth time
Length of admission
Time frame: 1-2 weeks after delivery
Time in hours between complete cervical dilation and birth time
Length of second stage
Time frame: 1-2 weeks after delivery
Proportion of women who required induction of labor
Induction of labor
Time frame: 1-2 weeks after delivery
Proportion of women who required augmentation of labor
Augmentation of labor
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Time frame: 1-2 weeks after delivery
Proportion of women who received an epidural
Epidural use
Time frame: 1-2 weeks after delivery
Type of delivery
Mode of delivery
Time frame: 1-2 weeks after delivery
Proportion of women diagnosed with chorioamnionitis
Presence of maternal infection
Time frame: 1-2 weeks after delivery
APGAR scores of neonate
Neonatal clinical assessment
Time frame: 1-2 weeks after birth
Umbilical cord gas values
Neonatal laboratory assessment
Time frame: 1-2 weeks after birth
Proportion of newborns admitted to Intensive Care Nursery
Neonatal Intensive Care Unit admission
Time frame: 1-2 weeks after birth
Neonatal Intensive Care Unit length of stay in days
Length of stay in the Intensive Care Nursery
Time frame: 1-2 weeks after birth
Proportion of women with meconium present during labor
Presence of meconium
Time frame: 1-2 weeks after delivery
Patient responses (yes or no) to a 4-question survey conducted after delivery to determine satisfaction with morphine and promethazine as a form of therapeutic rest.
Patient satisfaction assessment
Time frame: 1-4 weeks after delivery