The purpose of this research study is to determine whether the CB1R availability is lower in synthetic psychoactive cannabinoid subjects using the most widely available synthetic psychoactive cannabinoids at the time the study is initiated.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
OTHER
Masking
NONE
Enrollment
15
The radiotracer, \[11-C\]OMAR will be administered at no more than 10 micrograms at the beginning of each PET scan.
Connecticut Mental Health Center
New Haven, Connecticut, United States
Positron Emission Tomography (PET Imaging)
CB1R availability using \[11-C\]OMAR PET imaging Change in CB1R availability (e.g. volume distribution).
Time frame: Change in CB1R availability from baseline throughout one test day
CogState Battery
2\. Changes in Cognition during withdrawal using a computerized battery Changes in cognitive functions such as attention, memory, motor functioning, and processing speed.
Time frame: Change in CB1R availability from baseline throughout one test day
Electroencephalogram
3\. Changes in brain rhythms measured by Electroencephalography Changes in electroencephalographic (EEG) brain rhythms related to information processing.
Time frame: Change in CB1R availability from baseline throughout one test day
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