Patients with inflammatory bowel disease (IBD) often suffer from muscle weakness and a low bone mineral density as a consequence of systemic Inflammation and disease treatment limiting Quality of life in a considerable way. Exercise interventions to build up muscle mass and increasing physical function are promising Tools to improve the whole muscular Status of those patients. However, in the acute Phase of IBDs conventional Training methods may be too strenous, also because patients are suffering from acute gastrointestinal symptoms and feel fatigued. Due to those symptoms, patients present low Food intake and great loss of nutrients and energy especially by diarrhea. Individualized nutritional Support may be helpful to avoid malnutrition. The aim of this pilot study is to investigate the effect of a combined exercise and Nutrition Intervention using the gentle Training method of whole-body electromyostimulation (WB-EMS) combined with a individual high Protein nutritional Support on muscle mass, Body composition, physical function, Quality of life and gastrointestinal symptoms in outpatients with IBD.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
NONE
Enrollment
75
WB-EMS training is performed 2x/week for 12 weeks; Stimulation protocol: Frequency of 85 Hz, pulse duration of 0.35 ms, stimulation period of 6 sec, resting period of 4 sec; supervised by certified training instructors/physiotherapists participants perform simple exercises during the stimulation period following a video tutorial
dietary monitoring by dietary records; nutritional counselling by dietician, dietary advices: 1.5 g/kg bodyweight/day
Universitätsklinikum Erlangen, Medizinische Klinik 1
Erlangen, Bavaria, Germany
RECRUITINGSkeletal muscle mass
assessed by bioelectrical impedance analysis in kg
Time frame: 12 weeks
Body composition
assessed by bioelectrical impedance analysis in kg or %
Time frame: 12 weeks
Physical function - isometric muscle strength
isometric hand grip strength assessed by hand dynamometer
Time frame: 12 weeks
Physical function - Endurance
Six-minute-walk test (walking distance in m)
Time frame: 12 weeks
Physical function - lower limb strength
isometric lower limb strength assessed by isometric force plates in N
Time frame: 12 weeks
Quality of Life
IBDQ-D
Time frame: 12 weeks
Physical activity
IPAQ
Time frame: 12 weeks
Disease activity (Crohn's disease)
Harvey Bradshaw Index
Time frame: 12 weeks
Disease activity (ulcerative colitis)
Mayo Score
Time frame: 12 weeks
Inflammation status
C-reactive protein (CRP)
Time frame: 12 weeks
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