Myeloid-derived Suppressor Cells in Sepsis

Inclusion Criteria: * Patients must have known origin of infection . * Systemic inflammatory response syndrome. Exclusion Criteria: * age less than 18 years * pregnancy * known anaphylactoid reaction to colloid fluids * a life expectancy less than 24 hours, * inability to provide informed, written consent * Patients receiving nephrotoxic drugs, * admitted to the hospital following a surgical procedure, * sepsis more than 72 hours when screening .