Clinical Monitoring, MRI and Neuro-Ophthalmology of a Cohort of Patients With a Clinically Isolated Syndrome (CIS)

University Hospital, Lille134 enrolled

Overview

The purpose of this study is to develop tools to detect, measure, monitor and predict axonal damage in the course of CIS and during Multiple sclerosis (MS), in order to be able to consider as early as possible an adaptation of the background treatment in patients with MS. patients with radiological criteria of poor long-term clinical course.

Study Type

OBSERVATIONAL

Enrollment

134

Conditions

Clinically Isolated Syndrome Multiple Sclerosis

Eligibility

Sex: ALLMin age: 18 YearsMax age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Any patient who has had a CIS of less than 4 months (+/- 15 days), with at least 1 inflammatory lesion on his initial brain MRI or with normal brain MRI associated with the presence of oligoclonal bands in the CSF, Exclusion Criteria: * Atypical CIS for a first relapse of multiple sclerosis (extensive myelitis, bilateral retrobulbar optic neuritis immediately) * CIS dating more than 4 months (+/- 15 days) * Corticotherapy in the last 4 weeks

Locations (1)

Hôpital Roger Salengro, CHRU de Lille

Lille, France

Outcomes

Primary Outcomes

severity of the disease defined by Expanded Disability Status Scale (EDSS) ≥ 2.0

Time frame: At 5 years

Secondary Outcomes

Occurrence of a second push

Time frame: At 5 years

Occurrence of progression of the EDSS (Expanded Disability Status Scale) score

The scale evaluated the pyramidal, cerebellar, sensory, visual and mental functions . These make it possible to obtain a quotation between 0 and 10. The walk is called "normal" from 0 to 3.5. The walk is hampered from 4 and impossible from 7.5. The coast of 10 corresponds to the death of the patient. This measure differentiates two groups: severe EDSS and non-severe EDSS group,

Time frame: At 5 years

Occurrence of a handicap objectified by the Multiple Sclerosis Functional Composite(MSFC)

Time frame: At 5 years

variation of parameters measuring axonal pain / degeneration in MRI

Time frame: At 5 years

variation of parameters measuring axonal pain / degeneration in OCT

Time frame: At 5 years

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.