Testosterone-Dependent Effects on Protein Biomarkers From Healthy Males

Lund University30 enrolled

Overview

The study is designed to identify and validate new protein biomarkers in blood related to testosterone activity. Thirty healthy young males underwent pharmaceutical castration to lower testosterone levels. After three weeks the subjects received an intramuscular injection of testosterone undecanoate. Blood samples from just before pharmaceutical castration, three weeks after castration, and one week after injection of testosterone undecanoate were collected representing normal testosterone levels, low testosterone levels, and testosterone at eugonadal levels.

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Hypogonadism, Male

Interventions

GnRH antagonistDRUG

Eligibility

Sex: MALEMin age: 20 YearsMax age: 30 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: healthy males Exclusion Criteria: use of anabolic steroids, use of narcotics,

Outcomes

Primary Outcomes

Protein biomarkers

Finding new protein biomarkers related to testosterone response

Time frame: 48 months

Data from ClinicalTrials.gov

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