The objective of this research project is to determine in elderly subjects (\>50 year old) by 31P-MRS the brain concentration of phosphorous metabolites species and fluxes, before and after consumption of 2 commercially available oral nutrition products
Inclusion Criteria:
* Men and women aged between 50 and 75 years
* Healthy, based on the medical screening visit
* Normal BMI for age (18.5-29.9 kg/m2)
* Able to understand and to sign a written informed consent prior to trial entry
* Informed consent signed
Exclusion Criteria:
* Known type 1 or type 2 diabetes, on anamnesis
* Family history of type 2 diabetes (parents)
* Any other metabolic disease possibly impacting the postprandial glucose and insulin response (on anamnesis, to the opinion of the medical expert)
* Malabsorptive disorders including but not limited to pancreatitis, Crohn's disease, etc, to the opinion of the medical expert
* Any ongoing medication impacting dietary fat absorption and metabolism like statins, bile acid sequestrants, lipid lowering medications, or fibrates , to the opinion of the medical expert
* Any ongoing medication impacting the postprandial glucose and insulin response (like beta blockers), to the opinion of the medical expert
* Any ongoing medication impacting brain metabolism or function (neuroleptics, antidepressants, anti-epileptics), to the opinion of the medical expert
* Ongoing chemotherapy
* Any food supplement intake (e.g. MCT, ketone salts = Calcium, Sodium, Potassium, Magnesium) or special diet (e.g. ketogenic diet) possibly impacting basal ketone levels, to the opinion of the medical expert.
* Claustrophobia
* Hearing disorders (the participant placed into the MRS tunnel should be able to hear from the operators, for safety purpose)
* Having any metallic, electronic, magnetic, or mechanical implants, devices, or objects, for safety reason linked to magnetic field exposure (MRS):
* Aneurysm clip(s)
* Cardiac pacemaker
* Implanted cardioverter defibrillator (ICD)
* Electronic implant or device
* Magnetically-activated implant or device
* Neurostimulation system
* Spinal cord stimulator
* Cochlear implant or implanted hearing aid
* Insulin or infusion pump
* Implanted drug infusion device, like portacath® for instance
* Any type of prosthesis or implant
* Artificial or prosthetic limb
* Any metallic fragment or foreign body
* Hearing aid
* Other implant
* Subject injured by a metallic object or foreign body
* Allergy to cow milk or soy proteins
* Currently participating or having participated in an investigational trial during the past month
* Subjects not willing and/or not able to comply with scheduled visits and the requirements of the research protocol.
* Subject having a hierarchical link with the investigator or co-investigators.
Locations (1)
École Polytechnique Fédérale de Lausanne (EPFL) / Center for Biomedical Imaging (CIBM)
Lausanne, Switzerland
Outcomes
Primary Outcomes
The change in brain NAD+/NADH ratio (RX) after the intake of the nutrition products
Time frame: 31P metabolites and fluxes will be measured during one hour 2 times, one before product intake (control) and the second one 45 min after product intake"