Rapid Action Insulin (RAI) absorption and action measured by time to reach maximum insulin concentration and glucose infusion rate.
The investigators hypothesize that RAI absorption and action measured by time to reach maximum insulin concentration and glucose infusion rate during the clamp study will be significantly faster when insulin bolus is delivered using the "Quick Bolus" feature as compared to the "Standard Bolus". Outcomes were updated at time of results entry.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Enrollment
11
Individuals with Type 1 Diabetes (T1D) given 0.2 units/kg of rapid acting insulin (RAI) via "quick bolus" of 15 units per minute during a euglycemic clamp.
Individuals with Type 1 Diabetes (T1D) given 0.2 units/kg of rapid acting insulin (RAI) via "standard bolus" of 1.5 units per minute during a euglycemic clamp.
Yale University
New Haven, Connecticut, United States
Time to Maximum Glucose Infusion Rate
time to maximum glucose infusion rate (GIR) in minutes
Time frame: 300 minutes
Earlier Clearance of Exogenous Insulin.
Time to reach baseline insulin concentrations is used to determine the completion of insulin as part bolus of bioavailability.
Time frame: up to 5 hours
Maximum Glucose Infusion Rate
maximum glucose infusion rate (GIRmax)
Time frame: 300 minutes
Area Under the Curve for the Glucose Infusion Rate
area under the curve for the glucose infusion rate
Time frame: 300 minutes
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