Evaluation of Oncoxin-Viusid® in Prostate Cancer

Inclusion Criteria: * Masculine \>18 years-old patients * Performans status: Karnofsky ≥ 70 or (ECOG \<2) * Hormonal treatment alternatives 6 or 8 weeks before the inclusion ,with resistence to hormonal treatments * Normal laboratory tests to onco-specific treatments. * Ecocardiogram with a eyección fraction \> 60 %, in patients with history of cardiovascular deseases. * Patients with life expectative more than 6 months. Exclusion Criteria: * Patients who are receiving another onco-specific product in research. * Patients with known hypersensitivity to anthracyclines and / or mitoxantrone * Decompensated intercurrent diseases, including: active infections, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, liver damage and psychiatric illnesses that could limit adherence to the requirements of the clinical trial or any other special condition that at the discretion of the physician put your health and life at risk during the study or your participation in the trial. * Patients with cerebral metastases. * Patients with HIV.