This study determines the effect of olive oil and bran oil on antioxidant levels, and glycemic control in patients with type 2 diabetes mellitus (DM) Intervention: Patient type 2 DM will receive olive oil and bran oil with cross over study
Diabetes mellitus (DM) has become one of the global public health problems. The chronic complications of type 2 DM can be macrovascular and microvascular complications that can decrease the quality of life of the patient. The main goal of sustainable DM nutrition therapy is to keep glucose in the blood close to normal levels to stop hyperglycemic and hyperlipidemic events that may inhibit further complications This study was a clinical trial with cross over study design, random allocation, and double blindness to compare changes in antioxidant, glucose, cholesterol and triglyceride levels supplemented with 15 ml / day of olive oil (KZ) with supplementation of 15 ml / day of bran oil (KB). Provision of oil for 4 weeks in a row. During the 2-week interval not being treated (wash out). After the wash out period cross-over by exchanging olive oil supplementation to rice bran and vice versa for 4 consecutive weeks. The research will be conducted at Family Clinic Clinic FKUI Kayu Putih, Jakarta.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
10
Fkui-Kdk Kiara
Jakarta Pusat, DKI Jakarta, Indonesia
Change of malondialdehyde
Change from baseline malondialdehyde at 4 weeks and at 10 weeks, is measured in pmol/mL
Time frame: baseline at Day0 and ,midline at Day28 and endline at Day70
Change of fasting plasma glucose
Change from baseline fasting plasma glucose at 4 weeks and at 10 weeks, is measured in mg/dL
Time frame: baseline at Day0 and ,midline at Day28 and endline at Day70
Change of post prandial blood glucose
Change from baseline post prandial blood glucose at 4 weeks and at 10 weeks, is measured in mg/dL
Time frame: baseline at Day0 and ,midline at Day28 and endline at Day70
Change of total cholesterol
Change from baseline cholesterol at 4 weeks and at 10 weeks, is measured in mg/dL
Time frame: baseline at Day0 and ,midline at Day28 and endline at Day70
Change of Low density lipoprotein
Change from baseline Low density lipoprotein at 4 weeks and at 10 weeks, is measured in mg/dL
Time frame: baseline at Day0 and ,midline at Day28 and endline at Day70
Change of High density lipoprotein
Change from baseline High density lipoprotein at 4 weeks and at 10 weeks, is measured in mg/dL
Time frame: baseline at Day0 and ,midline at Day28 and endline at Day70
Change of Trygliseride
Change from baseline trygliseride at 4 weeks and at 10 weeks, is measured in mg/dL
Time frame: baseline at Day0 and ,midline at Day28 and endline at Day70
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Change of Katalase
Change from baseline katalase at 4 weeks and at 10 weeks, is measured in unit/ mg protein
Time frame: baseline at Day0 and ,midline at Day28 and endline at Day70
Change of Superoxide Dismutase
Change from baseline superoxide dismutase at 4 weeks and at 10 weeks, is measured in unit/ mg protein
Time frame: baseline at Day0 and ,midline at Day28 and endline at Day70
Change of Glutahione
Change from baseline gluthatione at 4 weeks and at 10 weeks, is measured in nmol/ gram
Time frame: baseline at Day0 and ,midline at Day28 and endline at Day70