Determining Whether Multiple Anesthesia Exposures Affect Cognitive Function for Retinoblastoma Patients

Memorial Sloan Kettering Cancer Center75 enrolled

Overview

The purpose of this study is to see if there is a difference between the development of the brain (neurodevelopment) in children who have been treated for retinoblastoma with multiple anesthetic exposures, compared with brain development in children who have never had anesthesia.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Pediatric Retinoblastoma Retinoblastoma

Interventions

Wechsler Intelligence Scale for Children, Fifth Edition (WISC-V)OTHER

the WISC-V assessment produces a Full Scale IQ (FSIQ) used for primary power consideration in this study. The FSIQ is the most comprehensive global ability score on the WISC-V, and it has been conventionally reported and interpreted as an estimation of overall intellectual ability

California Verbal Learning Test, Children's VersionOTHER

Used to assess verbal learning and memory in children and adolescents

Beery Developmental Test of Visual Motor Integration, 6th editionOTHER

Helps assess visual-motor skills in children and adults.

Eligibility

Sex: ALLMin age: 6 YearsMax age: 17 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age ≥ 6 and \< 17 years old Exclusion Criteria: * Diagnosis of any secondary disease associated with developmental delay * History of second cancer diagnosis * Legal Blindness * Past surgery of any type, with the exception of enucleation for retinoblastoma * Past exposure to anesthesia for surgical intervention * More than one anesthesia encounter for surgical intervention before diagnosis at MSK * Past External Beam Radiation for treatment of retinoblastoma * Past systemic chemotherapy * Non-native speaker of English; however, children whose parents speak only Spanish will be included, because the tests for parents are available in Spanish

Locations (1)

Memorial Sloan Kettering Cancer Center

New York, New York, United States

RECRUITING

Outcomes

Primary Outcomes

Comparing scores in neuropsychological testing results

The primary outcome is based on the Wechsler Intelligence Scale for Children, 5th edition (WISC-V) measured at follow up. The 5 primary index scores on the WISC-V (Verbal Comprehension, Visual Spatial, Fluid Reasoning, Working Memory, and Processing Speed) are based on 10 subtests and represent intellectual functioning in different cognitive areas. Similar to the FSIQ, the primary index scores are on a standard score metric with a mean of 100 (SD=15). The WISC-V consists of 16 subtests; each subtest is based on a scaled score metric with a mean of 10 and standard deviation (SD) of 3. Performance on these domain-specific subtests will be summarized and analyzed similarly to the FSIQ.

Time frame: 6 weeks

Central Contacts

Vittoria Arslan Carlon, MD

CONTACT

212-639-2680 arslancv@mskcc.org

David Abramson, MD

CONTACT

212-639-7232 abramsod@mskcc.org

Data from ClinicalTrials.gov

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