The Effects of Position on the Oxygenation Instability of Premature Infants as Documented by SpO2 Histograms

Rambam Health Care Campus23 enrolled

Overview

SpO2 instability is in the nature of premature infants. Hypoxic episodes occur spontaneously in many of these infants, especially after the first week of life. Different interventions have been shown to influence the incidence of hypoxemic episodes in premature infants. A few studies point towards potential clinical benefits of better oxygenation and less hypoxic events by positioning very low birth weight infants prone, though a recent meta-analysis didn't find a clear benefit of prone position. The aim of this study is to evaluate the changes in oxygenation among preterm infants receiving respiratory support when positioned prone versus supine, as documented by SpO2 histograms.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

NONE

Enrollment

Conditions

Premature Infant Bronchopulmonary Dysplasia

Interventions

Each subject will serve as his or her own control. Half of the infants will be placed supine for 3 hours, followed by 3 hours of prone positioning and back to supine for 3 hours and the other half will be start in prone position with consecutive periods of supine and then prone

Eligibility

Sex: ALLMin age: 14 Days

Medical Language ↔ Plain English

Inclusion Criteria: Premature infants with a weight \< 1500 g who are receiving respiratory support Exclusion Criteria: Congenital anomalies, acute lung pathology for example x-ray confirmed pneumonia, air leak, active culture proven sepsis or on inotropic support for low blood pressure.

Outcomes

Primary Outcomes

Oxygenation instability

SPO2 histogram documents the oxygenation stability. we will record the histogram at the end of each period of time and compare it

Time frame: 3 hours in each position