Esophageal achalasia is a precancerous condition for epidermoid carcinoma; incidence and risk factors for cancer development are not defined. Incidence and risk factors for epidermoid carcinoma development in achalasia patients were investigated.
In order to define incidence and risk factors for epidermoid carcinoma 681 patients affected by esophageal achalasia observed since 1973 were followed up with no time limits according to a prospective follow-up protocol. The local institutional review board approved using the database from the division of thoracic surgery for research purposes. Clinical, radiological and endoscopic data of achalasia patients were collected and analyzed.
Study Type
OBSERVATIONAL
Enrollment
681
Achalasia patients were periodically submitted to clinical assessment, barium swallow (esophageal diameter and residual barium column were measured), endoscopy. Mucosal esophageal biopsies were taken in order to diagnose dysplasia or epidermoid carcinoma.
Division of Thoracic Surgery Maria Cecilia Hospital
Cotignola, RA, Italy
RECRUITINGDetection of epidermoid carcinoma of the esophagus
Detection of epidermoid carcinoma of the esophagus by means of upper GI endoscopy
Time frame: 1 year
Result of achalasia treatment by investigating dysphagia and gastro-esophageal reflux
Result of achalasia treatment assessed by means of semiquantitative grading scales of dysphagia and gastro-esophageal reflux
Time frame: 1 year
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.