Allogeneic ABCB5-positive Limbal Stem Cells for Treatment of LSCD

Inclusion Criteria: 1. Male or female patients aged 18 to 85 years 2. Patients with secondary bilateral or unilateral LSCD (injury that caused LSCD at least 6 months prior to inclusion) 3. Neovascularization: Vessel penetration of at least 2 quadrants, with central cornea involved 4. Patients understand the nature of the procedure and are providing written informed consent prior to any clinical trial procedure 5. Women of childbearing potential must have a negative blood pregnancy test at Visit 1 6. Women of childbearing potential must be willing to use highly effective contraceptive methods during the course of the clinical trial Exclusion Criteria: 1. Compromised eyelid mobility and/or symblepharon; patient can be re-screened after appropriate treatment 2. Presence of eyelid malposition; patient can be re-screened after appropriate treatment 3. Active local ocular or systemic infection and/or inflammation. Patient can be re-screened after infection and/or inflammation is resolved. 4. Tumor diseases or history of tumor disease 5. Active ocular neoplastic disease (exclusion will be based on investigator's assessment) 6. Corneal erosion or ulcer is bigger than 4 mm2; corresponding to less than 95% of continuous corneal epithelium. Patient can be re-screened after erosion or ulcer is resolved (≤ 4 mm2). 7. Positive for human immunodeficiency virus (HIV) 1 and/or 2 (diagnosed by serologic testing) 8. Clinically significant or unstable concurrent disease or other clinical contraindications to stem cell transplantation 9. History of glaucoma 10. Contraindications to trial related procedures/substances including 1. The surgical procedure (e.g. removing of the conjunctival pannus) 2. Contact lens complications due to contact lens use in the proposed trial (based on the Efron Grading scale for standard clinical reference for contact lens complications) 3. Tear secretion deficiency determined by Schirmer's test 4. Allergy, sensitivity or intolerance to components/excipients of the IMP/ per protocol pre-planned concomitant medications 5. Conjunctival scarring with fornix shortening 6. General anesthesia (in case general anesthesia is required) or local anesthesia 7. Immunosuppression (being mandatory concomitant therapy) 11. Intraocular pressure (IOP) of ≥30 mm Hg 12. History or clinical signs of stroke or transient ischemic attacks 13. Active or suspected ocular or periocular infections 14. Active or suspected intraocular inflammation 15. Further clinical contraindications to IMP application (exclusion will be based upon investigator's judgment) 16. Current or previous (within 30 days of enrollment) treatment with another IMP, or participation and/or under follow-up in another clinical trial 17. Previous participation in this clinical trial (except screening failure due to inclusion criterion 2 and/or exclusion criterion 1 and/or 2 and/or 3 and/or 6) 18. Known abuse of alcohol, drugs, or medicinal products 19. Patients unwilling or unable to comply with the requirements of the protocol 20. Lactating women 21. Evidence of any other medical conditions (such as psychiatric illness, physical examination, or laboratory findings) that may interfere with the planned treatment, affect the patient's compliance, or place the patient at high risk of complications related to the treatment 22. Employees of the sponsor, or employees or relatives of the investigator