The Researchers are trying to determine if 68Ga-DOTATATE PET/CT imaging will have a similar accuracy as 18FDG PET/CT in diagnosing cardiac sarcoidosis and if it will be able to do so without the need for complex patient dietary preparation that is required with 18FDG PET/CT.
Prospective study of 15 consecutive patients with suspected or newly diagnosed cardiac sarcoidosis (CS) who are referred for a clinically indicated 18FDG (and 13NH3) PET/CT scan for cardiac sarcoidosis (CS) will be approached to undergo a 68Ga-DOTATATE PET/CT scan. Comparison will then be made between the 68Ga-DOTATATE PET/CT and the 18FDG and 13NH3 PET/CT to determine if 68Ga-DOTATATE detects CS.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
15
5.4 mCi of 68Ga-DOTATATE will be administered by intravenous route.
This scan will be performed as part of the planned clinical care for the patient. Dose of 18FDG will be administered intravenously in accordance with the institutional policy and accepted norms. CT attenuation scan will also be performed as part of this examination per institutional protocol.
This scan will be performed as part of the planned clinical care for the patient. Dose of 13NH3 will be administered intravenously in accordance with the institutional policy and accepted norms. CT attenuation scan will also be performed as part of this examination per institutional protocol.
Mayo Clinic in Rochester
Rochester, Minnesota, United States
68Ga-DOTATATE Uptake With Cardia Sarcoidosis (CS)
The number of subjects with areas of abnormal myocardial increased focal uptake
Time frame: 3 days
18FDG Uptake With Cardia Sarcoidosis (CS)
The number of subjects with areas of abnormal myocardial increased focal uptake on 18FDG scan
Time frame: 2 days
13NH3 PET/CT Uptake With Cardia Sarcoidosis (CS)
The number of subjects with areas of perfusion deficits on 13NH3 PET/CT scan
Time frame: 2 days
Physician Confidence in Study Interpretation
A Physician survey will be conducted for those cardiac imagers assessing both the DOTATATE and FDG studies to determine their confidence level in interpreting the studies and if one study was easier to interpret than the other
Time frame: 2 days
Subject Satisfaction
A patient survey will be conducted after each subject has undergone both the DOTATE and the FDG scans. Patient satisfaction will be measured by the question, "Which study did you prefer?" Subject to circle one of the following: 18FDG, 68Ga-DOTATATE or Equal
Time frame: 2 days
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