Cabergoline As An Adjuvant To Clomiphene Citrate For Management Of Unexplained Infertility

Assiut University120 enrolled

Overview

Infertility refers to an inability to conceive after having regular unprotected sex. Infertility can also refer to the biological inability of an individual to contribute to conception, or to a female who cannot carry a pregnancy to full term. In many countries infertility refers to a couple that has failed to conceive after 12 months of regular sexual intercourse

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

120

Conditions

Infertility

Interventions

Clomiphene Citrate 50mgDRUG

oral tablets

Cabergoline Oral TabletDRUG

oral tablets

Placebo Oral TabletDRUG

oral tablets

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 35 Years

Medical Language ↔ Plain English

Inclusion Criteria: * unexplained infertility, Primary or secondary. * Absence of galactorrhoea. * Normal serum prolactin. * Normal hysterosalpingography. * Normal spermogram. Exclusion Criteria: * Women on other line of treatment as aromatase inhibitors,gonadotrophins, or tamoxifen. * Known hypersensitivity for cabergoline or clomiphene citrate. * Other factors of infertility as tubal factor, uterine factor or male factor.

Outcomes

Primary Outcomes

The number of mature follicles

the follicles reach the size of 18 mm

Time frame: 14 days

Data from ClinicalTrials.gov

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