Muscle Evaluation Using Ultrasound in the Critically Ill

University Hospital, Montpellier100 enrolled

Overview

Critical illness is associated with ICU acquired weakness and diaphragmatic dysfunction. Ultrasound can evaluate the muscle mass non invasively and provides the ability for a muscle follow up during and after the ICU stay. Magnetic stimulation of the phrenic nerves and the measure of the end expiratory tracheal pressure with an occlusion valve allows to evaluate the diaphragm force production in mechanically ventilated patients. The aim of the present study is to constitute an image bank and to describe the muscle mass and function recovery in critically ill patients.

Critical illness is associated with ICU acquired weakness and diaphragmatic dysfunction. Ultrasound can evaluate the muscle mass non invasively and provides the ability for a muscle follow up during and after the ICU stay. Magnetic stimulation of the phrenic nerves and the measure of the end expiratory tracheal pressure with an occlusion valve allows to evaluate the diaphragm force production in mechanically ventilated patients. The aim of the present study is to constitute an image bank and to describe the mass and function recovery in critically ill patients. Ultrasound and clinical data will be collected and analysed during the ICU stay.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Critical Illness ICU Acquired Weakness

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Critically ill patients with at least one organ failure defined, organ failure being defined by a SOFA equal or above 3 for the organ, and an expected duration of ICU stay equal of above 3 days Exclusion criteria: \- Pregnancy, age below 18, absence of consent

Locations (1)

Uhmontpellier

Montpellier, France

Outcomes

Primary Outcomes

Ultrasound characteristics of the quadriceps

Changes in ultrasound characteristics of the quadriceps : cross sectional area of quadriceps (cm2)

Time frame: Since admission at day 0 and measured repetitively by 48 hours untildischarge from ICU or date of death from any cause, whichever came first, assessed up to day 28

Data from ClinicalTrials.gov

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