Evaluation of the Effect of a Shiitake Extract on Lipid Profile in Subjects With Moderate Hyperlipidemia

Inclusion Criteria: * Men and women from 18 to 65 years old. * BMI ≥18.5 and \<30 kg/m2. * Adequate cultural level and understanding for the clinical trial. * Signed informed consent. * Cardiovascular risk \<10% to 10 years measured by REGICOR. * Total cholesterol ≥ 200 mg/d and at least 2 factors included in the following list: * ≥ 45 years or women ≥ 55 years. * Family history of cardiovascular disease (CVD) in first degree male relative less than 55 years of age and less than 65 years in women. * HDL cholesterol: men \<40 or women \<50. * Triglycerides ≥ 150mg/dL and \<200 mg/dL * LDL cholesterol ≥ 130mg/dL and \< 160mg/dL * Smoker * Willingness to follow a healthy diet, hyperlipidemic control diet and a diet without stanols, sterols and yeast. * Social or familiar environment that prevents from accomplishing the dietary treatment Exclusion Criteria: * Individuals diagnosed with Diabetes Mellitus type 1. * Individuals diagnosed with Diabetes Mellitus type 2 on pharmacological treatment (unless it is possible the suspension 30 days before the trials). * Individuals with dyslipidemia on pharmacological treatment; * Individuals with hypertension on pharmacological treatment; * Individuals \> 60 years smokers with total cholesterol \> 200mg/dL or LDL \>130mg/dl. * Individuals with hypertension on pharmacological treatment uncontrolled. * Individuals with hyperthyroidism and hypothyroidism on pharmacological treatment uncontrolled. * Individuals allergic to Shiitake (Lentinula edodes) * Individuals with chronic diseases (hepatic, kidney, …) * Individuals receiving at least the preceding 2 months a pharmacological treatment that modifies the lipid profile (for example, statins, fibrates, diuretics, corticosteroids, ADOs); * Individuals who have participated in the last 6 months in a program or clinical trial to lose weight. * Smokers wanting to stop to smoke during the period that clinical trial lasts. * Individuals with mental illness. * Consume drugs to lose weight during 30 days before starting the study * Pregnant or breastfeeding women.