Thiamine as a Renal Protective Agent in Septic Shock

Number of Participants Receiving Renal Replacement Therapy

Number of participants who received renal replacement therapy in thiamine and placebo groups.

Time frame: From date of enrollment until discharge from the intensive care unit (ICU) or date of death, whichever comes first, up to 60 days after enrollment

ICU Free Days

Days alive and free of the ICU through day 28

Time frame: From date of enrollment until 28 days after enrollment

In-hospital Mortality

Length of hospital stay truncated at 60 days

Time frame: From date of enrollment until discharge from the hospital or date of death, whichever comes first, up to 60 days after enrollment

Number of Participants Experiences Acute Renal Failure

Acute renal failure as defined by the KDIGO (Kidney Disease Improving Global Outcomes) AKI (Acute Kidney Injury) criteria. In brief, a patient can meet these criteria if their serum creatinine increases (for example, serum creatinine increases to 1.5x or higher of baseline serum creatinine, or if it crosses 4mg/dL), or if renal replacement therapy is initiated, or if urine output decreases (for example, \<0.5ml/kg/hour for 6-12 hours) or if patient becomes anuric (no urine production).

Time frame: From date of enrollment until day of discharge from the index ICU admission or date of death, whichever comes first up until 60 days post-enrollment

Change in Lactate Level

Change in lactate level between enrollment and 72 hours after enrollment