This study is to evaluate the renal function of HMG-CoA reductase add-on in chronic kidney disease patients with proteinuria.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
374
Telmisartan/Rosuvastatin 40/10mg qd for 48 weeks
Telmisartan 40mg qd for 48 weeks
Wonju Severance Christian Hospital
Wŏnju, Gangwon-do, South Korea
RECRUITINGHallym University Sacred Heart Hospital
Rate of change from baseline to week 48 in Urine Protein to Creatinine Ratio (UPCR)
Time frame: baseline, week 48
Change from baseline to week 24 in UPCR
Time frame: baseline, week 24
Change from baseline to week 24 and week 48 in Urine Albumin-to-Creatinine Ratio (UACR)
Time frame: baseline, week 24, week 48
Change from baseline to week 24 and week 48 in estimated glomerular filtration rate (eGFR)
Time frame: baseline, week 24, week 48
Change from baseline to week 48 in UPCR
Time frame: baseline, week 48
Change from baseline to week 48 in high-sensitivity CRP (hs-CRP)
Time frame: baseline, week 48
Change from baseline to week 48 in HOMA-insulin resistance (HOMA-IR)
Time frame: baseline, week 48
Change from baseline to week 48 in 24hr urine protein
Time frame: baseline, week 48
Proportion of subjects whose UPCR decreased by more than 30% at 48 weeks
Time frame: baseline, week 48
Change from baseline to week 48 in MCP-1 (monocyte chemoattractant protein 1)
Time frame: baseline, week 48
Change from baseline to week 48 in urinary 8-isoprostane
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Anyang-si, Gyeonggi-do, South Korea
Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do, South Korea
RECRUITINGKorea University Ansan Hospital
Ansan, Gyeonggido, South Korea
RECRUITINGChonbuk National University Hospital
Jeonju, Jeollabuk-do, South Korea
RECRUITINGDong-A University Hospital
Busan, South Korea
NOT_YET_RECRUITINGKyungpook National University Hospital
Daegu, South Korea
RECRUITINGChungnam National University Hospital
Daejeon, South Korea
NOT_YET_RECRUITINGInje University Ilsan Paik Hospital
Goyang, South Korea
RECRUITINGThe Catholic University of Korea Incheon St.Mary's Hospital
Incheon, South Korea
RECRUITING...and 6 more locations
Time frame: baseline, week 48
Change from baseline to week 48 in urine nephrin
Time frame: baseline, week 48
Change from baseline to week 48 in type IV collagen
Time frame: baseline, week 48
Proportion of subjects who received renal replacement therapy (dialysis or renal transplant) at 12, 24, 36, or 48 weeks
Time frame: baseline, week 12, week 24, week 36, week 48