Assessment of Biomarkers in Patients With Decompensated Heart Failure and Underlying Coronary Artery Disease

Inclusion Criteria: Group 1: Heart Failure with Coronary Artery Disease Subjects * Symptomatic heart failure (≥ 3 months) with most recently documented LVEF ≤ 40% (Echo must have been completed in last 12 months prior to enrollment.) * Significant underlying coronary artery disease as evidenced by: * previous myocardial infarction * prior coronary artery bypass graft * 50% coronary stenosis of one or more arteries and/or * history of percutaneous coronary intervention with or without stenting * Age 18 years or older at the first screening visit Group 2: Healthy Subjects • Age 18 years or older at the first screening visit and within 20% of mean age of Group 1 Subjects Exclusion Criteria: Group 1: * Documented history of "severe" valvular disease * Documented history of atrial fibrillation, ventricular fibrillation or ventricular tachycardia. * Recent or current use of anticoagulant medications such as fXa inhibitors, direct thrombin inhibitors, vitamin K antagonists, or heparin. (within 1 month of screening) Group 2: * Known significant cardiovascular or hematological condition * Recent or current use of anticoagulant medications such as fXa inhibitors, direct thrombin inhibitors, vitamin K antagonists, or heparin. (within 1 month of screening) * Recent cold or flu symptoms, respiratory infection or surgery (within 2 weeks of screening) * History of Asthma * History of peptic ulcers