To date, all the electrophysiological methods for auditory testing rely on the measure on synchronous evoked auditory nerve activity. This measure only takes into account the response of the first action potential in every auditory fibber, but provides no information about the neural response during a sustained activity. This can explain why in experimental models, a loss of more of 80% of auditory nerve fibbers cannot be detected by usual electrophysiological measurements. In this study we aim at investigating the global spontaneous and sound evoked auditory nerve activity by recording directly the electrical field by an electrode placed directly on the auditory nerve of subjects during a skull base surgical procedure. We expected to demonstrated differences in the electrical activity between subjects with or without hearing loss.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
30
near field recording of auditory nerve activity with contact electrode
CHU Montpellier
Montpellier, France
Amplitude of global evoked auditory nerve activity
Time frame: 36 months
Spectrum of global evoked auditory nerve activity
Time frame: 36 months
Mesure of peristimulus time responses of evoked auditory nerve activity
Time frame: 36 months
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