It has previously been shown in healthy subjects, that a carbonated water containing a mix of amino acids and chromium picolinate can decrease postprandial blood glucose. Based on these findings, a flavored sparkling water product called Good Idea® with a proprietary blend of five amino acids and chromium picolinate has been developed. This product, along with an identical placebo, are included in this study to evaluate the effects on postprandial blood glucose in healthy, overweight adults when consumed with a standardized, high glycemic test meal. The study will be conducted in a cross-over design, double-blinded and placebo controlled, including 45 participants. The primary endpoint of the study is the incremental area under the curve (iAUC) for capillary blood glucose within 180 minutes after ingestion of the meal.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
44
The active carbonated water containing amino acids and chromium picolinate is consumed with a standardized test meal. Postprandial glucose and insulin response is documented for 180 minutes
The placebo carbonated water is consumed with a standardized test meal. Postprandial glucose and insulin response is documented for 180 minutes
Dept Experimental Medical Science, Lund University
Lund, Sweden
The three-hour incremental area under the curve (iAUC) for capillary blood glucose, 0-180 minutes
The incremental area under the curve for capillary blood glucose will be measured within 180 minutes after a test meal. Blood samples will be collected at 8 time points during the 180 minutes.
Time frame: 0, 15, 30, 45, 60, 90, 120 and 180 minutes post test meal
The three-hour iAUC for insulin, 0-180 minutes
The incremental area under the curve for intravenous blood insulin will be measured within 180 minutes after a test meal. Blood samples will be collected at 8 time points during the 180 minutes.
Time frame: 0, 15, 30, 45, 60, 90, 120 and 180 minutes post test meal
The three hour iAUC for intravenous glucose, 0-180 minutes
The incremental area under the curve for intravenous blood glucose will be measured within 180 minutes after a test meal. Blood samples will be collected at 8 time points during the 180 minutes.
Time frame: 0, 15, 30, 45, 60, 90, 120 and 180 minutes post test meal
The one-hour iAUC for intravenous Glucagon-like peptide 1 (GLP-1), 0-60 minutes
The incremental area under the curve for intravenous blood GLP-1 will be measured within 60 minutes after a test meal. Blood samples will be collected at 5 time points during the 60 minutes.
Time frame: 0, 15, 30, 45 and 60 minutes post test meal
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.