Pulmonary and Upper Limb Functions in Duchenne Muscular Dystrophy

Hacettepe University47 enrolled

Overview

Although it is known that the functions of pulmonary and upper limb is affected in late stage of Duchenne Muscular Dystrophy (DMD) negatively, the investigators do not have clear information about its early stage. The aim of this study was to investigate the differences in pulmonary and upper limb functions between children with DMD in early stage and healthy peers.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Duchenne Muscular Dystrophy Upper Limb Function Respiratory Function Test

Interventions

The Performance of Upper Limb Questionnaire (PUL)OTHER

Eligibility

Sex: MALEMin age: 5 YearsMax age: 10 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: children with DMD was; * age between 5-10 years * being on treatment with corticosteroids for more than 6 months * being at Level I according to Brooke Upper and Lower Extremity Classification Systems Healthy peers; * age between 5-10 years * not having any diagnosed disease Exclusion Criteria: • Children has undergo surgery and disease affect upper extremity or pulmonary function in last six months.

Outcomes

Primary Outcomes

Pulmonary Function Test (PFT)

The pulmonary function tests of the participants were evaluated with a spirometry. The child was asked to perform the spirometric tests for three times with maximum effort. The child was motivated before each attempt for stronger and longer expiration.The result of Pulmonary function Test were recorded.

Time frame: 5 minutes

The Performance Upper Limb (PUL)

Upper limb functions of participants were evaluated with The Performance of Upper Limb (PUL) scale. This scale, which was shown to be reliable in DMD, has 22 items in total. It consists of 3 different levels of function: high, mid, and distal. PUL also has four items determining timed performance.

Time frame: 15 minutes

Data from ClinicalTrials.gov

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