PLM60 for Peripheral T Cell Lymphoma (PTCL)

Key Inclusion Criteria: 1. Signed informed consent prior to study-related procedures 2. Patients with histologically confirmed relapsed or refractory PTCL, who were treated with at least 2 lines of standard therapy and for whom there is no known effective therapy. 3. Recovered from all toxicity from prior anticancer therapy based on clinical evaluation/ judgement of the Investigator 4. Participants must have an Eastern Cooperative Oncology Group (ECOG) performance score of 0-2. 5. Participants who have sufficient baseline organ function by laboratory evaluations 6. Left ventricular ejection fraction (LVEF) ≥ 50% 7. Life expectancy ≥ 16 weeks 8. Women of childbearing potential must have a negative pregnancy test prior to study entry, and agree to use adequate contraception from study entry through at least 3 months after the last dose of study drug 9. A male participant must agree to use adequate contraception; or female sexual partner who uses adequate contraception measures from study entry through at least 3 months after the last dose of study drug Additional Inclusion Criteria for Phase 2: 1. Involved lymph nodes or masses should be measurable in at least 2 perpendicular dimensions and be ≥ 1.5 cm in the longest of the perpendicular dimensions (based on Lugano Classification) 2. Agree to undergo pretreatment bone marrow biopsy and post treatment bone marrow biopsy when required to confirm response Key Exclusion Criteria: 1. Participants with a history of allergy to anthracyclines or liposomal drugs 2. Prior treatment with mitoxantrone, any anthracycline, or anthacenedione 3. Treatment with doxorubicin (with the exception of pegylated liposomal doxorubicin) with a total cumulative dose \> 300 mg/m2, or epirubicin with a total cumulative dose \> 500 mg/m2 4. Investigational treatment within 4 weeks of the start of PLM60 5. Prior allogeneic stem cell transplantation 6. Current symptomatic (uncontrolled) central nervous system tumor involvement 7. Certain types of cardiac impairment as defined in the protocol at the time of enrolment 8. Any concurrent active malignancy or concurrent malignancy diagnosis with less than 12 months disease free interval 9. Participants with evidence of an active infection 10. Participants with active bleeding 11. Participants who have had organ transplants